Recent advances in erythropoietic agents in renal anemia.

Evaluation of plasma erythropoietic-stimulating factors in anemic uremic patients.

HE ASSOCIATION of a moderately severe normochromic, normocytic anemia with chronic renal disease is well recognized. Diminished erythropoiesis,’3 hemolysis1’3’4 and hemorrhage5’#{176} have all been shown to contribute to the development of anemia in azotemic patients. However, diminished red cell production appears to be the predominant mechanism in renal anemia. The dynamics of this failure of...

Treating anemia of chronic kidney disease in the primary care setting: cardiovascular outcomes and management recommendations

Anemia is an underrecognized but characteristic feature of chronic kidney disease (CKD), associated with significant cardiovascular morbidity, hospitalization, and mortality. Since their inception nearly two decades ago, erythropoiesis-stimulating agents (ESAs) have revolutionized the care of patients with renal anemia, and their use has been associated with improved quality of life and reduced...

The anemia of chronic renal failure in sheep. Response to erythropoietin-rich plasma in vivo.

The hypoproliferative anemia in chronic renal failure has been assumed to be the result of decreased erythropoietin (Ep) production by the damaged kidney and of the shortening of erythrocyte survival. However, many in vitro studies suggest that erythropoietic inhibitors in uremic plasma may contribute to the anemia. To determine the in vivo relevance of uremic inhibitors, increasing amounts of ...

Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease Executive Summary

Chronic kidney disease (CKD) is the gradual, progressive deterioration of kidney function, and a condition that affects an estimated 26 million American adults. A common complication of CKD is anemia, which results from inadequate erythropoietin or from iron deficiency as a result of inadequate absorption or mobilization. The management of anemia in CKD patients must strike an appropriate balan...

Role of Immunosuppression Minimization Protocols in Renal Transplantation

The subject of transplant immunosuppression has generated significant interest in recent years. Excellent immunosuppression, advances in surgical technique, post-transplantation care, and infection control have resulted in excellent outcomes. There is widespread support for the notion that the fundamental objective in transplant immunology should be the achievement of specific graft toleran...

Microcytic anemia, erythropoietic protoporphyria and neurodegeneration in mice with targeted deletion of iron regulatory protein 2 Running title: iron-limited erythropoiesis in mice with IRP2 deletion